Abstract: Heat shock protein 70(HSP70)exists in cells widely, and is highly expressed in responsing to stress,it also plays an important role in composing and repairing the protein. The function of HSP70 in hepatocellular immunotherapy is becoming more and more important:Because of the specificity, immunogenicity and being molecular chaperone, HSP70can induces the immune responses. But it also has many questions which are needed to research for. In a word,HSP70 has a good prospect in the therapy of hepatocellular carcinoma.

Key words: Heat shock protein70, Hepatocellular carcinoma