Abstract: Objective To study the role of IgE high affinity receptor FcεR1 on HFD-induced non-alcoholic fatty liver disease (NAFLD) in mice. Methods To induce NAFLD, both WT and FcεR1-/- mice from each group (n=10, male) were fed with a high fat western diet for 12 weeks. Body weight was measured at a fixed time every week. All mice were sacrificed after 12 weeks treatment. Serum and liver were harvested to examine liver relevant parameters. Results Compared with WT mice, body weight and liver/body ratio in FcεR1-/- mice were increased (P<0.05). Meanwhile, serum AST and ALT, blood lipids (including TG, CHOL), hepatic TG and hepatic Collagen III mRNA levels were also significantly elevated in FcεR1-/- mice(P<0.01), indicating a more severe NAFLD symptom. Conclusions IgE high affinity receptor FcεR1 may have a protective effect on HFD-induced NAFLD,the mechanism may be reducing body weight and improving lipid metabolism.

Key words: Key words: IgE, FcεR1, NAFLD, Liver function