Abstract: Objective: To study the clinical feature and therapeutic effects of 16 patients diagnosed with multiple pituitary hormone deficiency with growth hormone deficiency (GHD). Methods: Clinical data of 16 cases were studied retrospectively. Results: 16 MPHD with GHD patients were included, containing 9 hypothyroidism, 13 hypogonadism and 6 ACTH deficiency. 10 of them had breech or foot presentation. The mean bone age was 11.0±3.5yr, delayed from chronological age, peak GH of L-Dopa provocation test was 0.14±0.17ng/mL. GH dose was 0.11±0.02IU/kg. After GH replacement therapy，the serum concentration of IGF-1 and growth velocity increased. Conclusion: GH replacement therapy is crucial once after one is diagnosed of MPHD excluding the hypothalamus and pituitary lesions. Other pituitary hormones must be replaced sufficiently for MPHD patients. There are no severe adverse events.

Key words: multiple pituitary hormone deficiency, hypopituitary, growth hormone, replacement therapy