Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (12): 1718-1722.
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Abstract: Phosphatase and tensin homologue deleted on chromosome 10(PTEN)is a protein contains lipid and protein phosphatase activity. The activation of PTEN and increased mitochondria or nuclear translocation after ischemia-anoxia in brain may determin the fate of neurons. Therefore, elucidation the molecular mechanisms of subcellular localization of PTEN after ischemia-anoxia would provide new insights in the target therapy of a large number of acute/chronic neurodegenerative disorders and drug design.
Key words: PTEN, ischemia, anoxia, neuron, subcellular localization
CLC Number:
R722
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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2016/V36/I12/1718