Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (10): 1407-1411.

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Expression and significance of C-erbB-2 and VEGF in sinonasal squamous cell carcinoma

  

  • Received:2015-12-03 Revised:2016-01-22 Online:2016-10-05 Published:2016-09-27

Abstract: Objective:To explore the expression and significance of C-erbB-2 and vascular endothelial growth factor (VEGF) in sinonasal squamous cell carcinoma(SNSCC). Methods: Immuno -histochemical method and Western blot method was used to determine the expression of C-erbB-2 and VEGF in specimen of sixty-two cases of sinonasal squamous cell carcinoma(SNSCC) ,thirty cases of nasal polyps﹙NP﹚and twenty-five cases of normal nasal mucosa. Results:The expression of C-erbB-2 and VEGF in SNSCC significantly higher than that in nasal polyps﹙NP﹚and normal nasal mucosa(P﹤0.05). Furthermore,the expression of C-erbB-2 and VEGF correlated with tumor classification,clinicopathologic stage,lymph node involvement(P﹤0.05),but not with patient’s age and gender.Conclusion: C-erbB-2 and VEGF are closely related to the tumorigenesis,differentiation and proliferation of SNSCC.Detection of these protein combined helps to diagnose and treatment of SNSCC.

Key words: Sinonasal neoplasms, squamous cell carcinoma, C-erbB-2, vascular endothelial growth factor, Immunohistochemical method, Western Blot