Abstract: Objective To explore the value of combined detection parathyroid hormone,PTH, interleukin-6,IL-6,cystatinC,Cys-C in differentiating acute and chronic renal failure. Methods 72 patients who diagnosed with acute renal failure(ARF), 162 the chronic renal failure(CRF) ,and 114 kidneys disease with non-renal failure(NRF) and 117 healthy people were detected and compared the levels of PTH,IL-6 and Cys-c.Analyse the diagnostic efficiency of each combination , PTH+IL-6,PTH+Cys-C,IL-6+ Cys-C,PTH+IL-6+ Cys-C,and evaluation with decision matrix. Results 1 .PTH of ARF group were significantly lower than CRF group (P <0.01) ;IL-6 of ARF group were significantly higher than healthy controls ,NRF group and CRF group (P <0.01);Cys-C of ARF group were higher than healthy controls and NRF group，were lower than CRF group (P<0.01). PTH,IL-6 and Cys-C of CRF group than healthy controls and NRF group were all significantly higher (P<0.01). Combination IL-6+Cys-C could increase LR+,CCR and YI index of ARF.And combined detection of PTH and Cys-C could obviously improve LR+ CCR and YI index of CRF.Conclusion Combine detection of IL-6+Cys-C and PTH+Cys-C is useful in differential diagnosis of ARF and CRF.

Key words: Parathyroid hormone, Interleukin-6, Cystatin-C, renal failure, differential diagnosis