Basic & Clinical Medicine ›› 2015, Vol. 35 ›› Issue (8): 1134-1138.

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Advances of multiplex ligation-dependent probe amplification technology on detection of gene deletions/duplications

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  • Received:2015-01-06 Revised:2015-03-23 Online:2015-08-05 Published:2015-07-15

Abstract: The multiplex ligation-dependent probe amplification (MLPA) technology used in detection of gene deletions/duplications not only helps in understanding the molecular mechanisms underlying the development of cancer, but also provides important information for disease diagnosis and prognosis. Currently, MLPA becomes a hotspot to be applied in testing tumor related gene deletions/duplications mutations.

Key words: MLPA, Tumor related gene, Deletions/duplications, Detection

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