Basic & Clinical Medicine ›› 2015, Vol. 35 ›› Issue (8): 1126-1129.

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The non-antibiotic effects of azithromycin and its clinical application progress

1,Jin TONG2   

  1. 1.
    2. the Second Affiliated Hospital, Chongqing Medical University
  • Received:2015-02-27 Revised:2015-04-22 Online:2015-08-05 Published:2015-07-15
  • Contact: Jin TONG E-mail:tongjin01234@163.com

Abstract: Azithromycin is a typical macrolide antibiotic with a 15-membered lactone ring and its non-antibiotic roles have been attracted increasingly great attention in recent years. The purpose of our present review is to summary the various non-antibiotic effects of azithromycin, including activities of anti-inflammation, immunomodulation, biofilm damage, regulation of airway mucus, change of macrophage phenotype and regulation of liquid electrolyte among airway surface, and simultaneously, its beneficial effects of long-term clinical application in treatment of lung disease with chronic infection with low dose as well as its nebulization efficiency.

Key words: Key words: azithromycin, non-antibiotic effects, atomization management

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