Basic & Clinical Medicine ›› 2015, Vol. 35 ›› Issue (12): 1686-1690.
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Abstract: IKKε known as a new IκB kinase(IKK)-related kinases play a vital role in regulating inflammation, innate immune response and oncogenesis through the activation of non-canonical NF-κB and IRF signaling cascades. Meanwhile, the role involved in the pathophysiology of metabolic diseases have gradually been found. IKKε have been closely linked to obesity, type 2 diabetes(T2DM)and non-alcoholic fatty liver disease(NAFLD)through the mechanism including producing inflammation, aggravating insulin resistance and effecting energy expenditure as well as andipokines secretion.
Key words: IKKε , type 2 diabetes, non-alcoholic fatty liver disease
CLC Number:
R589
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2015/V35/I12/1686