Abstract: Objective To assess the association of tag single nucleotide polymorphisms (tag SNPs) of plasma membrane calcium transporting ATPase1 (ATP2B1) gene with essential hypertension (EH) in Han population from Yunnan. Methods A case-control study was carried out. Twelve tag SNPs (rs10506974, rs10506975, rs2854371, rs957525, rs3741895, rs2681472, rs2070759, rs12423192, rs1050395, rs11105357, rs11105358 and rs7975689) and rs17249754 near the ATP2B1 gene were genotyped in 510 patients with EH and 510 healthy controls using polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Results The genotype and allele distributions of rs17249754 between the case subjects and controls had significant difference (P<0.01), and Logistic regression analysis showed that AA genotype and A allele reduced the risk of EH (OR=0.60, 95%CI 0.40~0.89, P<0.05; OR=0.73, 95%CI 0.60~0.88, P<0.01). Conclusions The rs17249754 near the ATP2B1 gene can be considered as a genetic marker for EH and A allele may be a protective factor for EH in Han population.

Key words: Key words: ATP2B1, essential hypertension, tag SNPs, Han population