Basic & Clinical Medicine ›› 2015, Vol. 35 ›› Issue (10): 1419-1423.

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Research progress in the long non-coding RNA ANRIL

  

  • Received:2015-03-17 Revised:2015-05-28 Online:2015-10-05 Published:2015-09-30
  • Contact: Che Jiang E-mail:jiang.c@vip.126.com

Abstract: Long non-coding RNAs are important regulators of gene expression. ANRIL which was coded on the Chr9p21.3 loci participates in the pathogenesis of tumor, coronary artery disease, type 2 diabetes mellitus and other diseases. Multiple ANRIL isoforms are tissue-specific. ANRIL mainly functions through Polycomb proteins, while there are also other downstream targets. The mechanism of each isoform and the downstream pathways are hotspots currently.

Key words: Long non-coding RNA, ANRIL, CDKN2BAS