Abstract: Objective To evaluate the topical anesthetic effects of Compound Lidocaine Cream (CLC) coated endotracheal tube on the prevention of cough/agitation during extubation in thyroidectomy under general anesthesia. Methods 42 patients scheduled for thyroidectomy in Peking Union Medical College Hospital were continuously enrolled in this prospective double-blinded randomized controlled trial. Patients were randomized into two groups. Group L were intubated with endotracheal tube coated with CLC, while the control group, Group C with liquid paraffin. The end point of study was spontaneous or induced cough/agitation during extubation. Hemodynamic parameters and the consumption of opioids were recorded. Patients were followed for major complications during their stay in hospital. Results Spontaneous cough/agitation rate was lower in Group L than Group C (15% vs. 65%, p<0.01) ；so was induced cough/agitation (35% vs. 90%, p<0.001) ；the value of SBP×HR was lower in Group L at 1 min after extubation (p<0.05). Conclusion The topical anesthetic effects of CLC coated endotracheal tube could prevent cough and agitation during extubation in thyroidectomy under general anesthesia.

Key words: Compound Lidocaine Cream, Topical anesthesia, thyroidectomy, cough/agitation