Abstract: Adiponectin(APN) is a newly discovered adipocytes-secreted protein having extensive biologic effect in anti-inflammatory and the regulation of lipid metabolism and insulin sensitivity, which may inhibit the development of nonalcoholic fatty liver disease. A large number of alleles single nucleotide polymorphisms (SNPs) appear in promoter region of adiponectin gene sequence of human. And part of SNPs are positively correlated with NAFLD, which are likely to provide a new means for the early diagnosis and therapy of NAFLD.

Key words: adiponectin, single nucleotide polymorphisms, nonalcoholic fatty liver disease