Abstract: Objective To observe the outcomes of endoscopic submucosal dissection(ESD) of early esophageal cancer and evaluate the efficacy and safety of ESD. Methods From June 2012 to March 2014, 49 cases of endoscopic resected esophageal superficial neoplasia were included. The mean age of the patients was 62.1±8.9 years. The average procedure time was 60.4±43.2 minutes.Results The enbloc resection rate was 94.3%and the R0 resection rate was 90.1%. The rate of immediate perforation was 7.8%, no postoperative bleeding and delayed perforation was recorded. The rate of esophageal stenosis was 6.1%. Extent of circumferential esophageal involvement (P<0.05) was associated with complications. Extent of circumferential esophageal involvement (P<0.01) and pathological type （P<0.05） were associated with a short procedure time. Conclusion ESD is an applicable method for Early esophageal Cancer with high rate of en bloc resection and complete resection, and it is effective and safety.

Key words: Early Esophageal Cancer, endoscopic submucosal resection(ESD), safty