Abstract: Non-resolving inflammation refers to a long-term non-homeostasis status under the action of infectious or non-infectious factors. There are studies showing that miRNA interacts with inflammation factors playing critical roles in the process of non-resolving inflammation related hepatocellular malignancy. Further investigation on the relationship between miRNA and inflammation factors during this process will be of great value to uncover the relationship between inflammation and tumor and innovate new therapy methods for non-resolving inflammation related malignant diseases.

Key words: non-resolving inflammation, microRNA, chronic viral hepatitis, liver fibrosis, hepatocellular carcinoma