Abstract: Objective To investigate the correlation between tumor necrosis factor-α (TNF-α)、 lipopolysaccharide（LPS）、phospholipase A2（PLA2）and platelet activating factor (PAF) with the blood coagulation function disorder in severe chest-abdominal injury and to study the effect of these factors on it．Methods 82 subjects with severe chest-abdominal injury were collected in the 253th Hospital of PLA from January in 2009 to June in 2012，of whom the trauma index were all above or equal to 17 points，and as the rescue and treatment were in progress the patients were examined platelet count (PLT)、D-dimer (D-D)、thromboplastin time（TT）、TNF-α、LPS、PLA2 and PAF for correlation analysis． Results PLT：83.4±38.5（109/L），D-D：1824±608（U/L），TT：58.3±12.4（s）；TNF-α：36.4±18.1（ng/ml）；LPS：344±106（IU/L）；PLA2：41.4±14.3（ng/ml）；PAF：15765±4432（ng/L）．To have evedently correlation between the blood coagulation function with injury factors．Conclusion TNF-α、LPS、PLA2 and PAF all participate in the process of the blood coagulation function disorder in severe chest-abdominal injury. The prophase interference in TNF-α、LPS、PLA2 and PAF is possible to improve the coagulation dysfunction in severe chest-abdominal injury．

Key words: 【Key word】 Severe chest - abdomen injury, Acute coaguiopathy, Tumor necrosis factor - α, Lipopolysaccharide, Phospholipase A2, Platelet - activating factor