Abstract: Sirtuins are class III histone deacetylase. SIRT1 and SIRT6 are the major members of Sirtuins participated in the development of chronic obstructive pulmonary disease(COPD). The expression of SIRT1 and SIRT6 were down-regulated in the lungs of patients with COPD, and they regulate inflammatory reaction, lung autophagy and senescence through multiple mechanisms. Sirtuins may be one of main regulatory molecules family in the progression of COPD.

Key words: COPD, Sirtuins, SIRT1, SIRT6