Abstract: Ovarian function has close association with division, proliferation and differentiation of oocytes and granulosa cells in ovary. Telomere, as a molecular clock measuring the ability of cell division, plays a critical role in division and differentiation of variant eukaryotic cells. Recent researches summerized premature ovarian failure based on telomere and telomerase.

Key words: Premature ovarian failure, telomere, telomerase, division and differentiation of cell