Abstract: RUNX3(hunan Runt-related transcription factor 3) playing important roles in regulation on cell proliferation,cell proliferation and cell apoptosis is a member of the Runt-related transcription factor family.The abnormal expression of RUNX3,such as heterozygous deficiency,hyper-methylation,has significant relationship to the occurrence,development,and prognosis of malignant tumor,and especially plays important roles in the occurrence and development of gastric cancer,colorectal cancer, and liver cancer.