Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (6): 866-869.

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RUNX3 and digestive system carcinoma

  

  • Received:2013-10-12 Revised:2013-11-21 Online:2014-06-05 Published:2014-05-26

Abstract: RUNX3(hunan Runt-related transcription factor 3) playing important roles in regulation on cell proliferation,cell proliferation and cell apoptosis is a member of the Runt-related transcription factor family.The abnormal expression of RUNX3,such as heterozygous deficiency,hyper-methylation,has significant relationship to the occurrence,development,and prognosis of malignant tumor,and especially plays important roles in the occurrence and development of gastric cancer,colorectal cancer, and liver cancer.