Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (3): 426-429.

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TGF-β signaling and hematopoietic malignancies


  • Received:2013-05-29 Revised:2013-10-08 Online:2014-03-05 Published:2014-02-27

Abstract: Transforming growth factor β (TGF-β) is a negative regulated cytokine for growth of hematopoietic cells. TGF-β/SMAD signaling pathway takes important part in pathogenesis of hematopoietic malignance diseases. The deficiencies of TGF-β expression and mutations of TGF-β receptors or downstream signaling pathways can cause malignant proliferation of hematopoietic cells. To study the signaling pathway of TGF-β may attribute to the recognize of the pathogenesis of hematopoietic malignances and the development of therapy targeting the TGF-β pathway.

Key words: TGF-β, signaling, hematopoietic, malignance

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