Abstract: CD44+、CD24+、CD166+ and CD29+ can be as colorectal cancer stem cell markers. They are involved in colorectal cancer incidence、invasion and recurrence, the higher expression of the worse prognosis. At the same time, the associated signal transduction pathways and proteases can adjust internal environment and involve in tumor formation. Based on studies of colorectal cancer stem cell surface markers, the early presence of the tumor can be detected, tumor recurrence are reduced, and find targets and breakthrough in diagnosis and treatment of colorectal cancer.

Key words: Key words:colorectal cancer, tumor stem cells(TSCs), maker