Abstract: CAFs (carcinoma-associated fibroblasts) are a rate-limiting determinant for growth and metastasis of cancers in tumor microenvironment. Studies recently have shown that MSCs (mesenchymal stem cells) can mainly differentiate to CAFs by TGF-β/Samd signaling pathways, and contribute to tumor growth, invasion, angiogenesis , metastasis through direct cell contacts and paracrine of various kinds of cytokines.

Key words: Mesenchymal stem cells, Carcinoma-associated fibroblasts, Cytokines