The effect of TLR3 signaling pathway on tumer cell apoptosis

Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (10): 1430-1433.

The effect of TLR3 signaling pathway on tumer cell apoptosis

Xiao-Jiao GAO¹,Li CHEN

Received:2013-12-26 Revised:2014-03-26 Online:2014-10-05 Published:2014-09-25
Contact: Li CHEN, E-mail:bl1@ntu.edu.cn

Abstract

Abstract: TLR3,a pattern recognition receptor（PRR）, recognizes pathogen associated molecular patterns (PAMPs) double-stranded RNA（dsRNA） to initiate immunity response. Recent publications demonstrated that TLR3 played an important role in promoting cells apoptosis in a range types of cells.Particularly, TLR3 tends to inducing cell apoptosis in tumor cells.This provides a potential evidence for tumor therapy by dsRNA.

Key words: TLR3 (toll like receptor 3), tumor cell, apoptosis, dsRNA（double-stranded RNA）

CLC Number:

R735

Xiao-Jiao GAO Li CHEN,. The effect of TLR3 signaling pathway on tumer cell apoptosis[J]. Basic & Clinical Medicine, 2014, 34(10): 1430-1433.

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The effect of TLR3 signaling pathway on tumer cell apoptosis

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