Abstract: Objective The result of the vein graft is poor as for restenosis. We want to investigate the effect of Notch signaling on restenosis of the vein graft. Methods Under the microscope rats were interposed the left jugular vein into the left common carotid artery, including control group, DAPT group and DMSO group. These data were measured including Media/Intima Ratio and PCNA. The expression level of Notch1 and HES1 protein was examined by Western blot. Result The protein level of Notch1 and HES1 were highly expressed in vascular smooth cells of vein graft. DAPT can inhibit the protein expression of both Notch1 and HES1 and the proliferation of vSMCs. Conclusion Notch signaling is crucial for restenosis of vein graft. The restenosis of vein graft is attenuated as the Notch signaling is inhibited.

Key words: Notch signal, vein graft, vSMCs