Abstract: Objective To observe the effect of ligand of peroxisome proliferators-activated receptor gamma (PPAR gamma) on the proliferation and secretion of trophoblast and choriocarnoma cells (JEG-3) and to study the role played by PPAR gamma during the process of JEG-3 activation. Methods We employed MTT assay observing the growth of the cells and IEMA observing the secretion of hcG in the cells. Matrigel invision chambers were performed to analyse the cell migration and invasion.Results The proliferation of JEG-3 was suppressed by PGZ with a low dose-dependent manner . The numbers of JEG-3 was obviously inhibited by PGZ（p<0.01）with increasing concentration.Conclusion The results obtained with this in vitro system demonstrated that PPARgamma activation could inhibit JEG-3 proliferation and invasiveness. PPARgamma may be considered as a new therapeutic target for gestational trophoblastic tumor in humans.

Key words: [Keywords]: gestational trophoblastic tumor (GTT), Peroxisome proliferator-activated receptors (PPARs), proliferation, chorionic gonadotropin(hcG), neoplasm invasion