Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (1): 130-133.
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Abstract: Pulmonary fibrosis is a refractory disease with high mortality. The expression of NOX4 mRNA can be activated and increased by TGF-beta1 which could induce the production of a large number of ROS. ROS could further activate Smad which involved in mediating the signaling pathway of TGF-β1/Smad leading to the occurrence of pulmonary fibrosis. Blocking the expression of NOX4 gene through varieties of technologies would disturb the signaling pathway of TGF-β1/Smad which may block the progress of pulmonary fibrosis. Therefore NOX4 may be the most promising therapeutic target in the process of pulmonary fibrosis.
Key words: acute lung injury, NOX4, pulmonary fibrosis , ROS, TGF-β1
CLC Number:
R318.13
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2014/V34/I1/130