Abstract: Objectives To evaluate the effect of Infliximab(IFX) and cyclosporin(CsA) as rescue therapy for patients with refractory-IBD. Methods Prospectively and not randomly, 18 cases with refractory-IBD were invited to participate in the study. Of 12 patients with UC, 6 cases received IFX; 6 patients took CsA. All of 6 patients with CD were given IFX. Comparing the effect of IFX with CsA at 12 weeks and 30 weeks. Results 5 UC cases responded to IFX and CsA, 1 case failed to therapy respectively for both groups at 14 weeks. Of 6 UC cases with IFX 3 were effects and 1 failed , but 4 cases responded and 1 case failed for CsA group at 30 weeks. Of 6 CD cases, 3 responded to IFX while 1 case failed at 14 weeks. Of 6 CD cases treated with IFX, 4 patients improved, no invalid case was found at 30 weeks. Rash occurred in 2 cases treated with IFX, while among cases treated with CsA, 1 developed tatter and 4 had hands tremor. Conclusions As rescue therapy for patients with refractory IBD, IFX and CsA presented the same effectiveness, Patients with good economic conditions had better take the fomer, those with relatively poor economic bear ability might as well choose the latter.

Key words: Infliximab, Cyclosporin, refractory IBD, short-term effect