Abstract: Objective To assess the clinical effect of continuous infusion of rocuronium with close-loop auto-feedback system on laparotomic hepatic surgery. Methods 30 patients (ASA I/II) who underwent hepatic surgery were randomized divided into continuous infusion of rocuronium group (group A, n=15) and intermittent bolus infusion group (group B, n=15). Recovery index, antagonistic time, recovery time and the average amount of rocuronium were compared between the two groups under muscle relaxants monitoring. Surgeons’ satisfactory scores were recorded. Results There was no significant difference inrecovery index between the two groups (P = 0.59> 0.05), while antagonistic and recovery time of group A wereshorter than those of group B (P <0.01), and both correlated with rocuronium average amount (at 0.01 level).Patients in both groups did not appear any respiratory complications or any other adverse events after extubation. Group B had higher satisfactory scores from surgeons (P <0.01). Conclusion Continuous infusion of rocuronium with close-loop auto-feedback system in hepatic surgery was safe. It reduced rocuroium’s amount, and could reduce the risks of residual neuromuscular blockade.

Key words: rocuronium, close-loop feedback system, hepatic surgery