Abstract: Objective To detect the effect of positive labial salivary glands pathology results derived from different methods for diagnosis of Sj?gren’s syndrome(SS). Methods From January 2009 to October 2010, 21 patients with SS and positive labial salivary glands pathology were studied. 10 of the biopsies were focal lymphocytic sialadenitis (FLS), with focus score (FS) ≥1 (group A). The presence of focal infiltrates of lymphocytes in labial gland interstitial tissue was defined as positive in the other 11 biopsies (group B). Clinical data were collected, and student's t-test, chi-square test were used to evaluate the effect of positive labial glands pathology results derived from different methods for diagnosis of SS. Results 1) The positive rate of arthralgia was significantly higher in group A than group B (p<0.01). 2) Group A’s left eye BUT was lower than group B, and the number of corneal fluorescein staining spot was more than group B, while the positive rate of left corneal staining was higher than group B (p<0.05). 3) There was no difference between two groups in positive rates of high titer ANA and anti-SSA/SSB antibodies. Conclusion The labial salivary glands pathology derived from the two different methods had no obvious difference in diagnosing SS.

Key words: primary sj?gren’s syndrome, labial salivary glands pathology, FLS, FS