Basic & Clinical Medicine ›› 2013, Vol. 33 ›› Issue (4): 439-443.
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Abstract: Objective To investigate whether MYH7 gene mutation and the ACE /DD genotype was associated with left ventricular hypertrophy (LVH) in Chinese essential hypertension . Methods We conducted a case-control study on 303 volunteers, 102 hypertensive with LVH and 101 hypertensive without LVH and 100 normal controls . Echocardiography measurement and calculation of left ventricular mass index (LVMI) . Polymerase chain reaction (PCR),restriction fragment length polymorphism (RFLP) detection ACE/DD genotype , double deoxidizing end sequencing method to detect MYH7 genetic mutations . Results with LVH group ACE gene frequency DD genotype significantly higher than the hypertensive without LVH group, the normal control group (P<0.01); MYH7 gene mutation is not found . Conclusion ACE gene polymorphism have significant relationship with high blood pressure LVH, DD genotype vulnerable to left ventricular hypertrophy . MYH7 gene mutations and hypertensive with LVH have no significant relationship , no evidences are found to support the association between the ACE /DD genotype as well as MYH7 gene mutation and LVH in essential hypertension.
Key words: essential hypertension , left ventricular hypertrophy , gene polymorphism , gene mutations
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2013/V33/I4/439