Abstract: Objective Research in xinjiang region kazak atrial fibrillation and potassium ion channels KCNE1-G38S genetic polymorphism of relevancy. Methods Collect the xinjiang region kazak atrial fibrillation (af group) and the crowd of people atrial fibrillation (control group) the 100 cases of peripheral blood sample specimens, extract DNA, the polymerase chain reaction-extinction enzymes fragment length polymorphism (PCR-RFLP), agarose electrophoresis analysis method appraisal KCNE1-G38S genotype and allelic distribution. Results KCNE1-G38S gene AA, AG, GG genotype frequency respectively in atrial fibrillation group 0.13 (13/100), 0. 34 (34/100) and 0.53 (53/100), in the control group were 0.10 (10/100), 0. 57 (57/100) and 0.33 (33/100), two groups of genotype distribution are statistically significant differences (P<0.05), and atrial fibrillation group G allele frequency (0.70) was much higher than those in the control group (0.515) (P<0.001). Conclusion Xinjiang region kazak the occurrence of af and KCNEl-G38S gene polymorphism related, KCNEl-G38S gene polymorphism site may exist race, regional differences.

Key words: atrial fibrillation, KCNE1, gene polymorphism, racial