Abstract: Medical gas has been widely used in clinical practice. Previously considered to be a physiological inert gas, hydrogen, not only has anti-oxidation effect, but also has anti-inflammatory and anti-apoptotic effect, and alleviates ischemia-reperfusion injury, atherosclerosis, metabolic syndrome and other systemic diseases. The biological effect of hydrogen gas is worth to be further investigated, and could start a novel field of biomedical research.

Key words: hydrogen gas, ischemic reperfusion, atherosclerosis