Cholesterol Metabolism of Macrophage Foam Cells and Atherosclerosis

Basic & Clinical Medicine ›› 2013, Vol. 33 ›› Issue (2): 235-238.

Cholesterol Metabolism of Macrophage Foam Cells and Atherosclerosis

Received:2011-12-26 Revised:2012-05-03 Online:2013-02-05 Published:2013-01-25

Abstract

Abstract: The formation of macrophage foam cells is in the early stage of the development of atherosclerosis. The transformation of macrophage foam cell involves the disruption of a homeostatic mechanism that controls the uptake, intracellular metabolism and ef?ux of cholesterol within macrophages.The research of the mechanism of foam cells has a great significance for the prevention and the treatment for the atherosclerosis.

Key words: Macrophage, Scavenger Receptor, ACAT, ABC transporter, CEH

CLC Number:

R5

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Cholesterol Metabolism of Macrophage Foam Cells and Atherosclerosis

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