Abstract: T2DM is a complex multi-gene disease,and 65 genes have been found whose gene variations were associated with T2DM with the help of GWAS in recent years. These genes play important roles in the development and function of pancreatic β cells, and also in peripheral insulin resistance. The find of associated genes with T2DM in GWAS provides new ideas for the intervention and treatment of T2DM.

Key words: Key words:Type 2 diabetes mellitus（T2DM）, Genome-wide association study（GWAS）, Single nucleotide polymorphisms（SNPs）