Abstract: Polycystic ovary syndrome is the most common endocrinal and metabolic disease in reproductive female. The etiology is still unclear. Building an appropriate animal model will improve the knowledge of etiology, pathogenesis, clinical strategies and the prevention for complication of PCOS. The previous animal models are induced by estrogen, androgen or constant illumination. Recently, new genetically modified animal model, such as transgenic, generalized knock-out or tissue specific knock-out mice were applied in the research of PCOS. The present review summarizes the origin, features, research progression, application and advantages/disadvantages of several PCOS-like mice, providing optimal model for research.

Key words: [Key words] Polycystic Ovary Syndrome, transgenic, animal model