Basic & Clinical Medicine ›› 2012, Vol. 32 ›› Issue (8): 939-942.
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Abstract: Objective: To measure the differences of compound A(CA)between low gas flow(500ml/min)and high gas flow(2L/min),and effects on renal and liver function. Methods:The general surgical patients(n=40)were randomized to low-flow anesthesia group and high-flow anesthesia group. Gas samples were taken from the aspiratory limbs of the anesthetic circuit in 30-minites interval during anesthesia. Analyze CA concentrations. Test the markers of hepatic and renal functions pre- and post-surgery. Results:There were no statistical differences between sevoflurane concentrations(0.97vs0.97MAC)and concentration-time-AUC(2.40vs2.41MAC-h).There were significant differences between concentrations(27.70vs11.54ppm)and concentration-time-AUC(55.76vs23.19ppm-h).All markers of hepatic and renal function(ALT、AST、Tbil、Dbil、BUN、Cr) were unchanged after anesthesia. Conclusion:CA concentrations and concentration-time-AUC between low-flow(500ml/min)and high-flow(2L/min) anesthesia were significantly different,but it did not result in any significant changes to markers of hepatic and renal functions,including、ALT、AST、Tbil、Dbil、BUN and Cr.
Key words: anesthesia, carbon dioxide absorbent, compound A(CA), sevoflurane
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2012/V32/I8/939