Basic & Clinical Medicine ›› 2012, Vol. 32 ›› Issue (7): 841-843.
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Abstract: Abstract:AP-2,a nuclear transcription factor family ,are involved in the regulation of cell proliferation, differentiation, apoptosis and carcinogenesis.At least 3 of the five AP-2 family members identified to date, AP-2a, AP-2βand AP-2γ, are related with the development of the breast cancer; transactivation fuction of AP-2 is regulated by tumor suppressor gene WWOX and P53、HER2 oncogene、trascriptional coactivators and AP-2 protein modifications.
Key words: activator protein-2, HER2 oncogene , breast cancer
CLC Number:
R 734
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2012/V32/I7/841