Basic & Clinical Medicine ›› 2012, Vol. 32 ›› Issue (5): 548-553.
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Abstract: [Abstract] Objective To research inducing apoptosis function of artesunate and explore the mechanism of inhibition effect of artesunate on esophageal cancer. Methods Cell apoptosis, cell cycle, bcl-2 and bax protein expression level of Eca109 cells after the treatment of various concentration of artesunate(Art) (0、10、20、40μg/ml) for 24h were detected by flow cytometry(FCM). Results Cell apoptosis of Eca109 cells was significantly increased after the treatment of Art for 24h (P<0.05). The Eca109 cell bcl-2 protein expression level and cell proliferation index(PI) of Art group were lower than control group (P<0.05), but the bax protein expression level was higher in a concentration-dependent manner. Conclusion Artesunate have the inhibition effect to esophageal cancer by regulating the bcl-2, bax protein expression level and cell proliferation so inducing cell apoptosis.
Key words: Flow cytometry, esophageal carcinoma, artesunate, cell apoptosis
CLC Number:
R735.1
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2012/V32/I5/548