Abstract: Abstract：Abnormal activated T cells infiltration and cytokine production are predominant mediators of skin pathology in psoriasis, a chronic inflammatory skin disease. Psoriasis has been definited as a T helper (Th) 1-type disease mediated by IL-12 、IFN-γ、TNF-α. Recently, Accumulating evidence suggests that IL-23 and the subsequent Th17 cell response it promotes are central factors in the pathogenesis of this disease.IL-23 is a central growth factor for Th17 cells as it influences both their differentiation and expansion.Th17-related cytokines including IL-17、 IL-21、IL-22 play a functional role in psoriasis and other Autoimmune diseases.

Key words: IL-23 , Th17, IL-17, Psoriasis