Basic & Clinical Medicine ›› 2012, Vol. 32 ›› Issue (2): 128-132.

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Comparison of immuno-modulatory properties between bone-marrow derived MSCs and adipose derived MSCs


  1. 1. Department of Oncology, PUMC Hospital, CAMS & PUMC
    2. Center for Tissue Engineering, Institute of Basic Medical Science,CAMS & PUMC
  • Received:2011-12-14 Revised:2012-01-12 Online:2012-02-05 Published:2012-01-12

Abstract: Objective To compare MSCs’ immuno-modulatory property between bone-marrow derived and adipose derived MSCs. Methods Phenotype analysis of both MSCs populations was detected by flow-cytometry. To analyse immuno-modulatory effect of MSCs, proliferation, cell cycle, activation, apoptosis and Th1/Th2 balance were analyzed after co-culturing lymphocytes and MSCs. Results Phenotype analysis showed that AMSCs had the similar expression of markers with BMSCs. Both AMSCs and BMSCs could inhibit T cells proliferation and activation. Also MSCs’ effect on Th cell differentiation into Th1 or Th2 was similar between AMSCs and BMSCs. Nevertheless, BMSCs could suppress activated T cell apoptosis, while AMSCs could not. Conclusion AMSCs and BMSCs showed similar immuno-modulatroy effect on T lymphocytes, however the difference effect on activated T cell apoptosis of the two cell populations was still unclear and the possible mechanism would be studied.

Key words: Bone marrow derived MSCs, Adipose derived MSCs, immuno-modulatory