Abstract: Abstract Islet microcvascular endothelial cells (IMECs) ,as themost pivotal part of microcirculation tissue barrier in islet , plays a critical role in islet endocrine function and pathogenesis of diabetes.It is well established abnormal glucose and lipid metabolism coexist in type 2 diabetes .Excessive lipotoxicity can cause IMECs injury and dysfunction directly by inducing oxidative stress,vasomotor dysfunction and cell apoptosis.In this review, we will describe the functional characteristics of IMECs and the possible mechanisms involved in the lipotoxicity induced cellular injury and dysfunction.

Key words: Key words:islet microvascular endothelial cells, type 2 diabetes , lipotoxicity , islet microcirculation