Abstract: Abstract：Bone mineral density(BMD), as an clinical marker for diagnosis of osteoporosis and assessment of fracture risk, is likely affected by multiple genetic and environmental factors. Recently, researches suggest that low-density lipoprotein receptor-related protein 5(LRP5) is closely related to bone mass and differentiation of osteoblasts. Furthermore, LRP5 is also associated to BMD and/or osteoporotic fracture. We review LRP5 gene locus, expression，structure，function and association between LRP5 and bone mass, in order to investigate the likely mechanisms of the association.

Key words: Low-density lipoprotein receptor-related protein 5(LRP5), Bone mass, Osteoblast