Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (9): 1060-1063.

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Research progress of low-density lipoprotein receptor-related protein 5 and bone mass

  

  • Received:2010-07-14 Revised:2010-10-11 Online:2011-09-05 Published:2011-09-05
  • Contact: Mei LI E-mail:limeilzh@yahoo.com

Abstract: Abstract:Bone mineral density(BMD), as an clinical marker for diagnosis of osteoporosis and assessment of fracture risk, is likely affected by multiple genetic and environmental factors. Recently, researches suggest that low-density lipoprotein receptor-related protein 5(LRP5) is closely related to bone mass and differentiation of osteoblasts. Furthermore, LRP5 is also associated to BMD and/or osteoporotic fracture. We review LRP5 gene locus, expression,structure,function and association between LRP5 and bone mass, in order to investigate the likely mechanisms of the association.

Key words: Low-density lipoprotein receptor-related protein 5(LRP5), Bone mass, Osteoblast

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