Abstract: Objective To explore the relativity of Epstein—Barr virus and diseases. Methods The related diseases of 110 Epstein—Barr virus infected patients with one or more than one of EBV IgG,IgA,IgM/VCA positive detected by immunoenzyme dyeing technique were analyzed retrospectively. Results There are 18 kinds related diseases in the Epstein—Barr virus infection of 110 cases. The most common disease caused by the Epstein—Barr virus infection is respiratory system infection. It accounted for 32.73%, followed by infections of hematologic system, digestive system, cardiovascular system, mononuclear phagocyte system and so on. Conclusion The Epstein—Barr virus infection may cause multiple system damage.