Abstract: Objective To investigate the impact of anti-anxiety/antidepressant treatment on the blood glucose profile in patients with type 2 diabetes.Method Sixty type 2 diabetes patients with a tendency of anxiety or depression, which was diagnosed according to the Zung Self-Rating Depression Scale (SDS) and Zung Self-Rating Anxiety Scale (SAS), were randomly assigned to received either anti-diabetic treatment solely，as the control group, or in combination with anti-anxiety or antidepressant therapy, as the intervention group. After 12-weak treatment, the changes in the index of anxiety (SDS)/depression (SAS), fasting blood glucose and HbA1C were compared between the two groups.Result Compared with that of before treatment , the SDS, SAS, FBG, and HbA1C were decreased significantly in both intervention group and control group, In intervention group , FBG decreased from 9.14±1.58mmol/L to 6.90±0.73 mmol/L, and HbA1C decreased form 9.88%±1.96% to 7.60%±1.00% respectively after treatment (P<0.05). In the control group, the corresponding parameters was 9.09±1.69mmol/L, and 9.68%±0.19% respectively before treatment, decreased to 7.60±0.81mmol/L，and 8.09%±0.83% respectively after treatment(P<0.05). The reduction in FBG and HbA1C was significantly greater in intervention group compared to control group. Conclusion: In type 2 diabetes patients with anxiety/depression tendency, anti-anxiety/antidepressant treatment can improve the blood glucose.

Key words: type 2 diabetes, anxiety, depression