Abstract: Objective To study the relationship of the expressions of PDCD5, MDM2, Tip60 and P53 in esophageal squamous cell cancer in Xinjiang. Methods RT-PCR was used to detect the mRNA of PDCD5, MDM2 and Tip60. The PDCD5, MDM2, Tip60 and P53 protein expressions were determined by using immunohistochemisry staining method. Results The positive incidence of PDCD5, MDM2 and Tip60mRNA expressions in 40 cases of the esophageal cancer tissues were 80.0﹪、65.0﹪、97.5﹪.The expression rate of MDM2mRNA in esophageal cancer was significantly higher than in normal esophagus mucosa and para-cancer tissue (P ＜0.05). Semi-quantitative analysis showed expression of PDCD5, MDM2 and Tip60mRNA have statistical difference in esophageal cancer and normal esophagus mucosa (P＜0.05).Expression rate of PDCD5, MDM2 and P53 proteins were lower in esophageal cancer than that in normal esophagus mucosa(P ＜0.05).The positive expression rate of PDCD5 protein in esophageal cancer were significantly correlated with tumor differentiation (P＜0.05). The expression of Tip60 and P53 protein，PDCD5 and MDM2mRNA were significant correlation(P ＜0.05). Conclusion It was speculated that there may be have a common transcription mechanism which constructed multiple pathways in cancer among PDCD5、MDM2、Tip60 and P53.