Abstract: Objective To evaluate the possible role of HR-HPV testing for ASC-H in clinical practice.Methods Among 17 125 cervical smesrs in China-Japan friendship hospital from June 2004 to April 2007 ,those interpreted as ASC and those had HR-HPV testing were enrolled in the study.The possible role of triage of HR-HPV testing for ASC-H was evaluated according to the results of biopsy.Results CIN 2/3 was identified in 25 of 52(48.1%) patients with HR-HPV positive ASC-H compared with 48 of 190 (25.2%)patients with HR-HPV positive ASC-US（P <0.01）. CIN 2/3 was identified on a follow-up in a similarly small proportion of both patients with HR-HPV negative ASC-H and patients with HR-HPV negative ASC-US (5.9%、5.7%，respectively).The sensitivity of HR-HPV testing in detecting CIN 2/3 for ASC-US and ASC-H was 82.8%,96.2% ,respectively;and the negative prective rate was 94.3%,92.3% ,respectively. Conclusions Patients with ASC-H and negative HR- HPV testing may be more efficiently managed by follow-up with regular Pap and HR-HPV testing rather than universal colposcopy.HR-HPV testing for triage of ASC-H in routine practice may have the same important triage role as for ASC-US.

Key words: HPV, cytology, colposcopy