Abstract: Objective To investigate the relationship between depressive disorder and inflammation markers in depressive rats induced by Forced Swimming Test (FST). Methods SD rats were randomly divided into controlling groups and modelling groups, Depression animal model was reproduced with FST in 21days. Modeling group included SS group (FST rats with 0.9% sodium cloride treated) and SI group (FST rats with Imipramine treated). all peripheral blood serum samples were respectively measured using enzyme linked immunoassay (ELISA) technique for concentration of MCP-1 and Immunoturbidimetric Assay for hsCRP. The expression of MCP-1 and NF-κB p65 in aorta tissue were observed by immunohistochemistry. Results There were high level of concentration of hsCRP and MCP-1 in peripheral blood serum samples and increased expression of MCP-1 and NF-κB p65 in aorta tissue of SS groups (P<0.05). SI groups had decreased the expression of inflammation markers in blood and aorta tissue. Conclusions Depressive disorder activate the inflammatory reaction with increased expression of NF-κB.