Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (5): 591-593.

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New insight of active vitamin D in chronic kidney disease

Dan LIU1,Lin-li LV2,Bi-cheng LIU1   

  1. 1. Medical College, Southeast University
    2.
  • Received:2010-05-17 Revised:2010-11-12 Online:2011-05-05 Published:2011-05-06
  • Contact: Bi-cheng LIU E-mail:liubc64@163.com

Abstract: Chronic kidney disease is usually complicated with deficiency of vitamin D which causes severe impairment of kidney function through stimulating RAS (renin–angiotensin system)and other pathways. Both in vivo and vitro studies have demonstrated that active vitamin D and its analogues supplementation could attenuate glomerulosclerosis and renal tubulointerstitial fibrosis and the renoprotective effects could delay the progression and reduce the mortality rate of CKD.

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