Abstract: Growth factor receptor-bound 7(Grb7), a member of Grb7 protein family, has three distinct functional regions: a lot of proline amino acids exist in its N terminal, and the mesial district has such similar amino acids sequence as that of MIG-10 protein from Caenorhabditis elegans, and a SH2 domain in its C terminal. With these different domain, Grb7 protein plays distinct roles in cellular signaling pathway. And if we know more about the biological function acted by different domains of Grb7 protein, we will make advances in treating of patients with high expression of Grb7 protein.