Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (11): 1287-1288.

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Relationship Between HIF-1α Expression and Angiogenesis in Non-small Cell Lung Cancer


  • Received:2010-11-02 Revised:2011-01-19 Online:2011-11-05 Published:2011-11-02

Abstract: Abstract Objective To investigate the expression and the relationship of angiogenesis of HIF-1αin non-small cell lung cancer(NSCLC).Methods  Immunohistochemical method was employed to detect the expression of HIF-1αand angiogenesis in tumor and laterotumor tissue of 55 patients .The vascular endothelial cell was marked in CD105. Results The positive rate of HIF - 1αin NSCLC tissue was 63.3%,and MVD was 23.12 ±7.22 , which were higher than those in the laterotumor tissue ( P < 0. 05). The expression of HIF-1αwas positively correlated with the angiogenesis , TNM stage and lymphatic metastasis. Conclusion It is suggested that HIF-1α is involved in the tumor angiogenesis in NSCLC.

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