Abstract: Abstract Objective To investigate the expression and the relationship of angiogenesis of HIF-1αin non-small cell lung cancer(NSCLC).Methods 　Immunohistochemical method was employed to detect the expression of HIF-1αand angiogenesis in tumor and laterotumor tissue of 55 patients .The vascular endothelial cell was marked in CD105. Results The positive rate of HIF - 1αin NSCLC tissue was 63.3%，and MVD was 23.12 ±7.22 , which were higher than those in the laterotumor tissue ( P < 0. 05). The expression of HIF－1αwas positively correlated with the angiogenesis , TNM stage and lymphatic metastasis. Conclusion It is suggested that HIF-1α is involved in the tumor angiogenesis in NSCLC.